Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers
This study aimed to formulate a pharmaceutical dosage form containing omeprazole (OMP) and curcumin (CURC) to treat experimental peptic ulcers. OMP and CURC were preliminarily complexed with hydroxypropyl-β-cyclodextrin for enhancing their solubilization. After that, the combined complex (CURC/OMP)...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/6/795 |
| _version_ | 1797593142064578560 |
|---|---|
| author | Eman J. Heikal Rashad M. Kaoud Shadeed Gad Hatem I. Mokhtar Afaf A. Aldahish Wafa Ali Alzlaiq Sawsan A. Zaitone Yasser M. Moustafa Taha M. Hammady |
| author_facet | Eman J. Heikal Rashad M. Kaoud Shadeed Gad Hatem I. Mokhtar Afaf A. Aldahish Wafa Ali Alzlaiq Sawsan A. Zaitone Yasser M. Moustafa Taha M. Hammady |
| author_sort | Eman J. Heikal |
| collection | DOAJ |
| description | This study aimed to formulate a pharmaceutical dosage form containing omeprazole (OMP) and curcumin (CURC) to treat experimental peptic ulcers. OMP and CURC were preliminarily complexed with hydroxypropyl-β-cyclodextrin for enhancing their solubilization. After that, the combined complex (CURC/OMP) was loaded to alginate beads to sustain their release and then coated with chitosan. Finally, we tested the anti-ulcerogenic impact of the best formula versus free OMP or OMP-only-loaded beads. The formulated spherical beads’ diameter ranged from a minimum value of 1.5 ± 0.08 mm to 2.6 ± 0.24 mm; the swelling results ranged from 400.00 ± 8.5% to 800.00 ± 6.2%. The entrapment efficiency was in a range from 60.85 ± 1.01% to 87.44 ± 1.88%. The optimized formula (F8) showed a maximum EE% (87.44 ± 1.88%), swelling (800.00 ± 6.2%), and diameter in the range of 2.60 ± 0.24, with a desirability of 0.941. In the first hour following the administration of the free drug complex, 95% of OMP and 98% of CURC were released. This is unacceptable for medications that require a delayed release in the stomach. The initial drug release from hydrogel beads was 23.19% for CURC and 17.19% for OMP after 2 h and 73.09% for CURC and 58.26% for OMP after 12 h; however, after 24 h, 87.81% of CURC and 81.67% of OMP had been released. The OMP/CURC beads showed a more stable particle size (0.52 ± 0.01 mm) after 6 weeks. In conclusion, the OMP/CURC hydrogel beads give stronger anti-ulcer effectiveness compared to free OMP, CURC-only beads, and OMP-only-loaded beads, indicating a prospective application for managing peptic ulcers. |
| first_indexed | 2024-03-11T02:03:38Z |
| format | Article |
| id | doaj.art-d12c34129d0f4b4dab54acf700a4a816 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T02:03:38Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-d12c34129d0f4b4dab54acf700a4a8162023-11-18T12:01:39ZengMDPI AGPharmaceuticals1424-82472023-05-0116679510.3390/ph16060795Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic UlcersEman J. Heikal0Rashad M. Kaoud1Shadeed Gad2Hatem I. Mokhtar3Afaf A. Aldahish4Wafa Ali Alzlaiq5Sawsan A. Zaitone6Yasser M. Moustafa7Taha M. Hammady8Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, EgyptPharmacy Department, Ashur University College, Baghdad 10047, IraqDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, EgyptDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University-Kantara Branch, Ismailia 41636, EgyptDepartment of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, EgyptThis study aimed to formulate a pharmaceutical dosage form containing omeprazole (OMP) and curcumin (CURC) to treat experimental peptic ulcers. OMP and CURC were preliminarily complexed with hydroxypropyl-β-cyclodextrin for enhancing their solubilization. After that, the combined complex (CURC/OMP) was loaded to alginate beads to sustain their release and then coated with chitosan. Finally, we tested the anti-ulcerogenic impact of the best formula versus free OMP or OMP-only-loaded beads. The formulated spherical beads’ diameter ranged from a minimum value of 1.5 ± 0.08 mm to 2.6 ± 0.24 mm; the swelling results ranged from 400.00 ± 8.5% to 800.00 ± 6.2%. The entrapment efficiency was in a range from 60.85 ± 1.01% to 87.44 ± 1.88%. The optimized formula (F8) showed a maximum EE% (87.44 ± 1.88%), swelling (800.00 ± 6.2%), and diameter in the range of 2.60 ± 0.24, with a desirability of 0.941. In the first hour following the administration of the free drug complex, 95% of OMP and 98% of CURC were released. This is unacceptable for medications that require a delayed release in the stomach. The initial drug release from hydrogel beads was 23.19% for CURC and 17.19% for OMP after 2 h and 73.09% for CURC and 58.26% for OMP after 12 h; however, after 24 h, 87.81% of CURC and 81.67% of OMP had been released. The OMP/CURC beads showed a more stable particle size (0.52 ± 0.01 mm) after 6 weeks. In conclusion, the OMP/CURC hydrogel beads give stronger anti-ulcer effectiveness compared to free OMP, CURC-only beads, and OMP-only-loaded beads, indicating a prospective application for managing peptic ulcers.https://www.mdpi.com/1424-8247/16/6/795omeprazolecurcuminhydroxypropyl-β-cyclodextrinchitosan-alginate hydrogelulcer |
| spellingShingle | Eman J. Heikal Rashad M. Kaoud Shadeed Gad Hatem I. Mokhtar Afaf A. Aldahish Wafa Ali Alzlaiq Sawsan A. Zaitone Yasser M. Moustafa Taha M. Hammady Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers Pharmaceuticals omeprazole curcumin hydroxypropyl-β-cyclodextrin chitosan-alginate hydrogel ulcer |
| title | Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers |
| title_full | Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers |
| title_fullStr | Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers |
| title_full_unstemmed | Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers |
| title_short | Design and Optimization of Omeprazole-Curcumin-Loaded Hydrogel Beads Coated with Chitosan for Treating Peptic Ulcers |
| title_sort | design and optimization of omeprazole curcumin loaded hydrogel beads coated with chitosan for treating peptic ulcers |
| topic | omeprazole curcumin hydroxypropyl-β-cyclodextrin chitosan-alginate hydrogel ulcer |
| url | https://www.mdpi.com/1424-8247/16/6/795 |
| work_keys_str_mv | AT emanjheikal designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers AT rashadmkaoud designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers AT shadeedgad designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers AT hatemimokhtar designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers AT afafaaldahish designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers AT wafaalialzlaiq designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers AT sawsanazaitone designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers AT yassermmoustafa designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers AT tahamhammady designandoptimizationofomeprazolecurcuminloadedhydrogelbeadscoatedwithchitosanfortreatingpepticulcers |