Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells

Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells

Second-generation antipsychotics (SGAs), in particular, olanzapine and clozapine, have been associated with the development of type 2 diabetes mellitus (T2D) and metabolic syndrome in individuals with schizophrenia. In this context, beta cell dysfunction is a plausible mechanism by which SGAs cause...

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Bibliographic Details
Main Authors: Diana Grajales, Patricia Vázquez, Rosa Alén, Ana B. Hitos, Ángela M. Valverde
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Metabolites
Subjects:
olanzapine
ER stress
beta cell
second-generation antipsychotics
schizophrenia
type 2 diabetes
Online Access:https://www.mdpi.com/2218-1989/12/5/443

Internet

https://www.mdpi.com/2218-1989/12/5/443

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