Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat

Abstract Combination therapy with focused ultrasound (FUS) and a neuroprotective agent, BNG-1, was examined in an acute carotid thrombotic occlusion model using LED irradiation in rat to improve the thrombolytic effect of rt-PA. Seven treatment groups included (A) intravenous bolus injection of 0.45...

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Bibliographic Details
Main Authors: Tsong-Hai Lee, Jih-Chao Yeh, Chih-Hung Tsai, Jen-Tsung Yang, Shyh-Liang Lou, Chen-June Seak, Chao-Yung Wang, Kuo-Chen Wei, Hao-Li Liu
Format: Article
Language:English
Published: Nature Portfolio 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01769-2