Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease

Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease

The present review analyzes the results of recent clinical trials of β secretase inhibition in sporadic Alzheimer’s disease (SAD), considers the striking dichotomy between successes in tests of β-site Amyloid Precursor Protein-Cleaving Enzyme (BACE) inhibitors in healthy...

Full description

Bibliographic Details
Main Authors: Vladimir Volloch, Sophia Rits
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Medical Sciences
Subjects:
Alzheimer’s disease
amyloid precursor protein
familial Alzheimer’s disease
sporadic Alzheimer’s disease
β-site amyloid precursor protein-cleaving enzyme 1 inhibitors
amyloid precursor protein-independent generation of β amyloid
Online Access:http://www.mdpi.com/2076-3271/6/2/45

Internet

http://www.mdpi.com/2076-3271/6/2/45

Similar Items