Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease

Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease

The present review analyzes the results of recent clinical trials of β secretase inhibition in sporadic Alzheimer’s disease (SAD), considers the striking dichotomy between successes in tests of β-site Amyloid Precursor Protein-Cleaving Enzyme (BACE) inhibitors in healthy...

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Bibliographic Details
Main Authors:	Vladimir Volloch, Sophia Rits
Format:	Article
Language:	English
Published:	MDPI AG 2018-06-01
Series:	Medical Sciences
Subjects:	Alzheimer’s disease amyloid precursor protein familial Alzheimer’s disease sporadic Alzheimer’s disease β-site amyloid precursor protein-cleaving enzyme 1 inhibitors amyloid precursor protein-independent generation of β amyloid
Online Access:	http://www.mdpi.com/2076-3271/6/2/45

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