A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation

A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation

Abstract The outcome of T cell activation is determined by mechanisms that balance Ca2+ influx and clearance. Here we report that murine CD4 T cells lacking Neuroplastin (Nptn −/−), an immunoglobulin superfamily protein, display elevated cytosolic Ca2+ and impaired post-stimulation Ca2+ clearance, a...

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Main Authors: Mark Korthals, Kristina Langnaese, Karl-Heinz Smalla, Thilo Kähne, Rodrigo Herrera-Molina, Juliane Handschuh, Anne-Christin Lehmann, Dejan Mamula, Michael Naumann, Constanze Seidenbecher, Werner Zuschratter, Kerry Tedford, Eckart D. Gundelfinger, Dirk Montag, Klaus-Dieter Fischer, Ulrich Thomas
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08519-4

Internet

https://doi.org/10.1038/s41598-017-08519-4

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