Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery

Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery

Precursor ribosomal RNA (pre-rRNA) processing is a key step in ribosome biosynthesis and involves numerous RNases. A HEPN (higher eukaryote and prokaryote nucleotide binding) nuclease Las1 and a polynucleotide kinase Grc3 assemble into a tetramerase responsible for rRNA maturation. Here, we report t...

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Bibliographic Details
Main Authors: Jiyun Chen, Hong Chen, Shanshan Li, Xiaofeng Lin, Rong Hu, Kaiming Zhang, Liang Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
HEPN nuclease
Pre-rRNA processing
ribosome biosynthesis
Online Access:https://elifesciences.org/articles/86847

Internet

https://elifesciences.org/articles/86847

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