Renal injury is accelerated by global hypoxia-inducible factor 1 alpha deficiency in a mouse model of STZ-induced diabetes

Renal injury is accelerated by global hypoxia-inducible factor 1 alpha deficiency in a mouse model of STZ-induced diabetes

Abstract Background Hypoxia inducible factor 1 (HIF-1) activates protective pathways to counteract hypoxia and prevent tissue damage in conjunction with renal injury. The aim of this study was to evaluate a role of HIF-1 in diabetes-induced kidney damage. Methods We used a streptozotocin-induced dia...

Full description

Bibliographic Details
Main Authors: Romana Bohuslavova, Radka Cerychova, Katerina Nepomucka, Gabriela Pavlinkova
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Endocrine Disorders
Subjects:
Diabetic complications
Diabetic nephropathy
Hypoxia
Podocyte
Mouse model
Online Access:http://link.springer.com/article/10.1186/s12902-017-0200-8

Internet

http://link.springer.com/article/10.1186/s12902-017-0200-8

Similar Items