hUMSCs regulate the differentiation of ovarian stromal cells via TGF-β1/Smad3 signaling pathway to inhibit ovarian fibrosis to repair ovarian function in POI rats

hUMSCs regulate the differentiation of ovarian stromal cells via TGF-β1/Smad3 signaling pathway to inhibit ovarian fibrosis to repair ovarian function in POI rats

Abstract Objective The basic pathological changes of primary ovarian insufficiency (POI) include ovarian tissue fibrosis and follicular development disorders. The human umbilical cord mesenchymal stem cell (hUMSC) transplantation has been shown an effective method to improve the ovarian function in...

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Bibliographic Details
Main Authors: Linlu Cui, Hongchu Bao, Zhongfeng Liu, Xuejing Man, Hongyuan Liu, Yun Hou, Qianqian Luo, Siyuan Wang, Qiang Fu, Hongqin Zhang
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Stem Cell Research & Therapy
Subjects:
Primary ovarian insufficiency
Human umbilical cord-derived mesenchymal stem cells
Ovarian stromal cells
TGF-β1 signaling pathway
Fibrosis
Online Access:http://link.springer.com/article/10.1186/s13287-020-01904-3

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http://link.springer.com/article/10.1186/s13287-020-01904-3

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