Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer

Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer

Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus investigated the toxic action of these Se agents...

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Bibliographic Details
Main Authors: Teresa W.-M. Fan, Jason Winnike, Ahmad Al-Attar, Alexander C. Belshoff, Pawel K. Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N. Lane
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Metabolites
Subjects:
non-small cell lung cancer
selenite
methylseleninic acid
selenomethionine
pyruvate carboxylation
glutaminolysis
Online Access:https://www.mdpi.com/2218-1989/13/7/774

Internet

https://www.mdpi.com/2218-1989/13/7/774

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