Evaluating Mono- and Combination Therapy of Meropenem and Amikacin against Pseudomonas aeruginosa Bacteremia in the Hollow-Fiber Infection Model

Evaluating Mono- and Combination Therapy of Meropenem and Amikacin against Pseudomonas aeruginosa Bacteremia in the Hollow-Fiber Infection Model

ABSTRACT Debate continues as to the role of combination antibiotic therapy for the management of Pseudomonas aeruginosa infections. We studied the extent of bacterial killing by and the emergence of resistance to meropenem and amikacin as monotherapies and as a combination therapy against susceptibl...

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Bibliographic Details
Main Authors: Minyon L. Avent, Kate L. McCarthy, Fekade B. Sime, Saiyuri Naicker, Aaron J. Heffernan, Steven C. Wallis, David L. Paterson, Jason A. Roberts
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
amikacin
meropenem
Pseudomonas aeruginosa
pharmacodynamic
hollow fiber infection model
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00525-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00525-22

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