Formation of ultralong DH regions through genomic rearrangement
Abstract Background Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single “ultralong” DH, IGHD8–2, encoding over 50 amino acids. Many bovine IGHD regions have sequence...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-06-01
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| Series: | BMC Immunology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12865-020-00359-8 |