ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids

ω-O-Acylceramides but not ω-hydroxy ceramides are required for healthy lamellar phase architecture of skin barrier lipids

Epidermal omega-O-acylceramides (ω-O-acylCers) are essential components of a competent skin barrier. These unusual sphingolipids with ultralong N-acyl chains contain linoleic acid esterified to the terminal hydroxyl of the N-acyl, the formation of which requires the transacylase activity of patatin-...

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Bibliographic Details
Main Authors: Lukáš Opálka, Jason M. Meyer, Veronika Ondrejčeková, Linda Svatošová, Franz P.W. Radner, Kateřina Vávrová
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Journal of Lipid Research
Subjects:
Skin
lipids
ceramides
sphingolipids
acylceramides
barrier function
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000591

Internet

http://www.sciencedirect.com/science/article/pii/S0022227522000591

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