A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells.

The human liver fluke, Opisthorchis viverrini, infects millions of people throughout south-east Asia and is a major cause of cholangiocarcinoma, or cancer of the bile ducts. The mechanisms by which chronic infection with O. viverrini results in cholangiocarcinogenesis are multi-factorial, but one su...

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Bibliographic Details
Main Authors: Michael J Smout, Thewarach Laha, Jason Mulvenna, Banchob Sripa, Sutas Suttiprapa, Alun Jones, Paul J Brindley, Alex Loukas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19816559/pdf/?tool=EBI