Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity and induces cognitive impairments, but the exact mechanism remains unclear. Astrocytes form interconnected networks in t...

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Bibliographic Details
Main Authors: Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Neuroinflammation
Subjects:
Isoflurane
Cognitive impairment
Connexin 43
Gap junctions
Astrocytic network
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-022-02424-y

Internet

https://doi.org/10.1186/s12974-022-02424-y

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