Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro

Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro

Abstract In Plasmodium vivax, the most studied vaccine antigens are aimed at blocking merozoite invasion of erythrocytes and disease development. Very few studies have evaluated pre-erythrocytic (PE) stage antigens. The P. vivax circumsporozoite protein (CSP), is considered the leading PE vaccine ca...

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Bibliographic Details
Main Authors: Francis Babila Ntumngia, Surendra Kumar Kolli, Pradeep Annamalai Subramani, Samantha J. Barnes, Justin Nicholas, Madison M. Ogbondah, Brian B. Barnes, Nichole D. Salinas, Pongsakorn Thawornpan, Niraj H. Tolia, Patchanee Chootong, John H. Adams
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-51820-2

Internet

https://doi.org/10.1038/s41598-024-51820-2

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