PP1C and PP2A are p70S6K Phosphatases Whose Inhibition Ameliorates HLD12-Associated Inhibition of Oligodendroglial Cell Morphological Differentiation

PP1C and PP2A are p70S6K Phosphatases Whose Inhibition Ameliorates HLD12-Associated Inhibition of Oligodendroglial Cell Morphological Differentiation

Myelin sheaths created by oligodendroglial cells encase neuronal axons to achieve saltatory conduction and protect axons. Pelizaeus-Merzbacher disease (PMD) is a prototypic, hereditary demyelinating oligodendroglial disease of the central nervous system (CNS), and is currently known as hypomyelinati...

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Bibliographic Details
Main Authors: Naoto Matsumoto, Yuki Miyamoto, Kohei Hattori, Akihiro Ito, Hironori Harada, Hiroaki Oizumi, Katsuya Ohbuchi, Kazushige Mizoguchi, Junji Yamauchi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomedicines
Subjects:
VPS11
HLD12
p70S6K
protein aggregate
oligodendroglial cell
morphological differentiation
Online Access:https://www.mdpi.com/2227-9059/8/4/89

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https://www.mdpi.com/2227-9059/8/4/89

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