Verubulin (Azixa) Analogues with Increased Saturation: Synthesis, SAR and Encapsulation in Biocompatible Nanocontainers Based on Ca<sup>2+</sup> or Mg<sup>2+</sup> Cross-Linked Alginate

Verubulin (Azixa) Analogues with Increased Saturation: Synthesis, SAR and Encapsulation in Biocompatible Nanocontainers Based on Ca<sup>2+</sup> or Mg<sup>2+</sup> Cross-Linked Alginate

Tubulin-targeting agents attract undiminished attention as promising compounds for the design of anti-cancer drugs. Verubulin is a potent tubulin polymerization inhibitor, binding to colchicine-binding sites. In the present work, a series of verubulin analogues containing a cyclohexane or cyclohepta...

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Bibliographic Details
Main Authors: Kseniya N. Sedenkova, Denis N. Leschukov, Yuri K. Grishin, Nikolay A. Zefirov, Yulia A. Gracheva, Dmitry A. Skvortsov, Yanislav S. Hrytseniuk, Lilja A. Vasilyeva, Elena A. Spirkova, Pavel N. Shevtsov, Elena F. Shevtsova, Alina R. Lukmanova, Vasily V. Spiridonov, Alina A. Markova, Minh T. Nguyen, Alexander A. Shtil, Olga N. Zefirova, Alexander A. Yaroslavov, Elena R. Milaeva, Elena B. Averina
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceuticals
Subjects:
tubulin polymerization inhibitor
apoptosis inducer
verubulin
pyrimidine
tetrahydroquinazoline
aromatic nucleophilic substitution
Online Access:https://www.mdpi.com/1424-8247/16/10/1499

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https://www.mdpi.com/1424-8247/16/10/1499

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