First‐in‐human application of double‐stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection

Abstract A double‐stranded RNA (dsRNA) phage phiYY is able to kill a pyomelanin‐producing Pseudomonas aeruginosa strain, which was isolated from a 40‐year‐old man with interstitial lung disease (ILD) and chronic lung infection. Phage therapy was used as a last resort for this patient. The three‐cour...

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Bibliographic Details
Main Authors: Linlin Li, Qiu Zhong, Yunze Zhao, Juan Bao, Bing Liu, Zhuojun Zhong, Jing Wang, Lan Yang, Tingting Zhang, Mengjun Cheng, Nannan Wu, Tongyu Zhu, Shuai Le
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Microbial Biotechnology
Online Access:https://doi.org/10.1111/1751-7915.14217