Non-targeted effects of photon and particle irradiation and the interaction with the immune system
Ionizing irradiation is an important clinical approach to treat solid tumors. Modern radiation technologies aim to selectively kill tumor cells and protect the surrounding normal tissue. The standard paradigm for radiation effects in cellular systems involves damage of the DNA including DNA double s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00080/full |
| _version_ | 1811193662562893824 |
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| author | Thomas Ernst Schmid Gabriele eMulthoff |
| author_facet | Thomas Ernst Schmid Gabriele eMulthoff |
| author_sort | Thomas Ernst Schmid |
| collection | DOAJ |
| description | Ionizing irradiation is an important clinical approach to treat solid tumors. Modern radiation technologies aim to selectively kill tumor cells and protect the surrounding normal tissue. The standard paradigm for radiation effects in cellular systems involves damage of the DNA including DNA double strand breaks, which are considered as most effective in destroying tumor cells. Due to their enhanced physical and radiobiological properties, high linear energy transfer (LET) radiation qualities are of special interest in tumor therapy. Future radiation therapy strategies aim to utilize carbon ions to effectively treat highly aggressive tumors. More recently, evidence is emerging for non-DNA targeted effects of radiation, including mutations, chromosomal aberrations and changes in gene expression, which can occur in cells that were not directly exposed to radiation. Radiation oncologists are only gradually beginning to appreciate the clinical relevance of radiation-induced bystander effects, genomic instability and abscopal effects. Since these effects are sensed by the immune system, a combination of immunotherapy and irradiation presents a new therapeutic opportunity in the future. |
| first_indexed | 2024-04-12T00:13:06Z |
| format | Article |
| id | doaj.art-d16680dcbea5453199b00da4946b8edd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T00:13:06Z |
| publishDate | 2012-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d16680dcbea5453199b00da4946b8edd2022-12-22T03:55:55ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2012-07-01210.3389/fonc.2012.0008030814Non-targeted effects of photon and particle irradiation and the interaction with the immune systemThomas Ernst Schmid0Gabriele eMulthoff1Klinikum rechts der Isar, Technische Universitaet Muenchen, GermanyKlinikum rechts der Isar, Technische Universitaet Muenchen, GermanyIonizing irradiation is an important clinical approach to treat solid tumors. Modern radiation technologies aim to selectively kill tumor cells and protect the surrounding normal tissue. The standard paradigm for radiation effects in cellular systems involves damage of the DNA including DNA double strand breaks, which are considered as most effective in destroying tumor cells. Due to their enhanced physical and radiobiological properties, high linear energy transfer (LET) radiation qualities are of special interest in tumor therapy. Future radiation therapy strategies aim to utilize carbon ions to effectively treat highly aggressive tumors. More recently, evidence is emerging for non-DNA targeted effects of radiation, including mutations, chromosomal aberrations and changes in gene expression, which can occur in cells that were not directly exposed to radiation. Radiation oncologists are only gradually beginning to appreciate the clinical relevance of radiation-induced bystander effects, genomic instability and abscopal effects. Since these effects are sensed by the immune system, a combination of immunotherapy and irradiation presents a new therapeutic opportunity in the future.http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00080/fullBystander EffectGenomic InstabilityImmune Systemabscopal effectphoton irradiationparticle irradiation |
| spellingShingle | Thomas Ernst Schmid Gabriele eMulthoff Non-targeted effects of photon and particle irradiation and the interaction with the immune system Frontiers in Oncology Bystander Effect Genomic Instability Immune System abscopal effect photon irradiation particle irradiation |
| title | Non-targeted effects of photon and particle irradiation and the interaction with the immune system |
| title_full | Non-targeted effects of photon and particle irradiation and the interaction with the immune system |
| title_fullStr | Non-targeted effects of photon and particle irradiation and the interaction with the immune system |
| title_full_unstemmed | Non-targeted effects of photon and particle irradiation and the interaction with the immune system |
| title_short | Non-targeted effects of photon and particle irradiation and the interaction with the immune system |
| title_sort | non targeted effects of photon and particle irradiation and the interaction with the immune system |
| topic | Bystander Effect Genomic Instability Immune System abscopal effect photon irradiation particle irradiation |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00080/full |
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