CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

Chimeric antigen receptor (CAR)-expressing T cells are a complex and heterogeneous gene therapy product with variable phenotype compositions. A higher proportion of less differentiated CAR T cells is usually associated with improved antitumoral function and persistence. We describe in this study a n...

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Bibliographic Details
Main Authors: Laura Kapitza, Naphang Ho, Thomas Kerzel, Annika M. Frank, Frederic B. Thalheimer, Arezoo Jamali, Thomas Schaser, Christian J. Buchholz, Jessica Hartmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
L-selectin
receptor-targeted viral vectors
LV
chimeric antigen receptor
CAR T cells
ΔLNGFR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183698/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183698/full

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