Intratumoral PD1<sup>+</sup>CD38<sup>+</sup>Tim3<sup>+</sup> CD8<sup>+</sup> T Cells in Pre-BCG Tumor Tissues Are Associated with Poor Responsiveness to BCG Immunotherapy in Patients with Non-Muscle Invasive Bladder Cancer

Intratumoral PD1<sup>+</sup>CD38<sup>+</sup>Tim3<sup>+</sup> CD8<sup>+</sup> T Cells in Pre-BCG Tumor Tissues Are Associated with Poor Responsiveness to BCG Immunotherapy in Patients with Non-Muscle Invasive Bladder Cancer

Intravesical immunotherapy with Bacillus Calmette–Guerin (BCG) is a standard of care therapy for non-muscle invasive bladder cancer (NMIBC), which accounts for about 75% of newly diagnosed urothelial cancer. However, given the frequent recurrence and progression, identification of a pre-treatment bi...

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Bibliographic Details
Main Authors: Debashree Basak, Soumya Mondal, Swadeep Kumar Srivastava, Deborpita Sarkar, Ishita Sarkar, Sukanya Basu, Arpita Bhoumik, Snehanshu Chowdhury, Dilip Kumar Pal, Shilpak Chatterjee
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
non-muscle invasive bladder cancer
BCG immunotherapy
CD8<sup>+</sup> T cells
biomarker
prognosis
Online Access:https://www.mdpi.com/2073-4409/12/15/1939

Internet

https://www.mdpi.com/2073-4409/12/15/1939

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