Mutagenic Analysis of the HIV Restriction Factor Shiftless

Mutagenic Analysis of the HIV Restriction Factor Shiftless

The interferon-induced host cell protein shiftless (SFL) was reported to inhibit human immunodeficiency virus (HIV) infection by blocking the –1 programmed ribosomal frameshifting (–1PRF) required for expression of the Gag-Pol polyprotein. However, it is not clear how SFL inhibits –1PRF. To address...

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Bibliographic Details
Main Authors: Niklas Jäger, Shreya Ahana Ayyub, Natalia Korniy, Frank Peske, Markus Hoffmann, Marina V. Rodnina, Stefan Pöhlmann
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
–1 programmed ribosomal frameshifting
shiftless
C19orf66
restriction factor
HIV-1
Online Access:https://www.mdpi.com/1999-4915/14/7/1454

Internet

https://www.mdpi.com/1999-4915/14/7/1454

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