Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing

Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing

Excessive amounts of free radicals are deleterious for cells, resulting in cell damage, affecting the wound healing process and causing premature ageing or even neoplastic transformation. Here the capacity of Manuka honey (MH) to protect against oxidative damage and improve the process of skin wound...

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Bibliographic Details
Main Authors: José Miguel Alvarez-Suarez, Francesca Giampieri, Mario Cordero, Massimiliano Gasparrini, Tamara Yuliet Forbes-Hernández, Luca Mazzoni, Sadia Afrin, Pablo Beltrán-Ayala, Ana María González-Paramás, Celestino Santos-Buelga, Alfonso Varela-Lopez, José Luis Quiles, Maurizio Battino
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Functional Foods
Subjects:
Manuka honey
ROS
AMPK
Nrf2
Wound healing
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616301220

Internet

http://www.sciencedirect.com/science/article/pii/S1756464616301220

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