Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

Abstract The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia from the lateral habenula (LHb) reportedly induces depression-like behaviors in mice. However, the key molecular mechanism that mediates major depressive disorder (MDD) pathogenesis remains elusive. W...

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Bibliographic Details
Main Authors: Lujuan He, Yi Zheng, Lixuan Huang, Jingyi Ye, Yinyi Ye, Hanyue Luo, Xi Chen, Wei Yao, Jiaxu Chen, Ji-chun Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-02227-y

Internet

https://doi.org/10.1038/s41398-022-02227-y

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