24h Quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice

24h Quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice

Mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (Mecp2) cause most cases of Rett syndrome (RTT). Currently there is no cure for RTT. Abnormal EEGs are found in 100% of RTT cases and are associated with severe sleep dysfunction, the cause of which is not well understood. Mice def...

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Bibliographic Details
Main Authors: Michael V Johnston, Simon eAmmanuel, Cliona eODriscoll, Amy eWozniak, Sakkubai eNaidu, Shilpa Dattatray Kadam
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Systems Neuroscience
Subjects:
Rett Syndrome
Glutamate
MeCP2
biomarkers
Sleep structure
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00118/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00118/full

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