Design, pharmacokinetic profiling, and assessment of kinetic and thermodynamic stability of novel anti-Salmonella typhi imidazole analogues

Abstract Background Typhoid fever, a disease caused by a gram negative bacterial species known as Salmonella typhi, constitutes a significant cause of morbidity and mortality, especially in developing nations of the world. Antibiotic therapy is the major treatment option currently but the rising inc...

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Bibliographic Details
Main Authors: John Philip Ameji, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba
Format: Article
Language:English
Published: SpringerOpen 2023-01-01
Series:Bulletin of the National Research Centre
Subjects:
Online Access:https://doi.org/10.1186/s42269-023-00983-5