The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis

The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis

Dehydroepiandrosterone (DHEA), a precursor of steroid sex hormones, is synthesized by steroid 17-alpha-hydroxylase/17,20-lyase (CYP17A1) with the participation of microsomal cytochrome b5 (CYB5A) and cytochrome P450 reductase (CPR), followed by sulfation by two cytosolic sulfotransferases, SULT1E1 a...

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Bibliographic Details
Main Authors: Anastasiya Tumilovich, Evgeniy Yablokov, Yuri Mezentsev, Pavel Ershov, Viktoriia Basina, Oksana Gnedenko, Leonid Kaluzhskiy, Tatsiana Tsybruk, Irina Grabovec, Maryia Kisel, Polina Shabunya, Natalia Soloveva, Nikita Vavilov, Andrei Gilep, Alexis Ivanov
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
cytochrome P450
cytosolic sulfotransferase
cytochrome b5
surface plasmon resonance
enzymatic assay
in silico modeling
Online Access:https://www.mdpi.com/1422-0067/25/4/2072

Internet

https://www.mdpi.com/1422-0067/25/4/2072

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