Oxidative stress mediates the inhibitory effects of Manzamine A on uterine leiomyoma cell proliferation and extracellular matrix deposition via SOAT inhibition

Oxidative stress mediates the inhibitory effects of Manzamine A on uterine leiomyoma cell proliferation and extracellular matrix deposition via SOAT inhibition

Uterine fibroids, the most common benign tumors of the myometrium in women, are characterized by abnormal extracellular matrix deposition and uterine smooth muscle cell neoplasia, with high recurrence rates. Here, we investigated the potential of the marine natural product manzamine A (Manz A), whic...

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Bibliographic Details
Main Authors: Li-Chun Lin, Hsin-Yi Chang, Tzu-Ting Kuo, Hsin-Yuan Chen, Wen-Shan Liu, Yii-Jwu Lo, Shih-Min Hsia, Tsui-Chin Huang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Redox Biology
Subjects:
Manzamine A
Uterine fibroid
SOAT
Cholesterol esterification
Oxidative stress
ER stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002628

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http://www.sciencedirect.com/science/article/pii/S2213231723002628

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