Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E2‐Induced Oxidative Stress in Hypertension

Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E2‐Induced Oxidative Stress in Hypertension

Background Prostaglandin E2 (PGE2) in the rostral ventrolateral medulla (RVLM) has been recognized as a pivotal pressor substance in hypertension, yet understanding of its effects and origins in the RVLM remains largely elusive. This study aimed to elucidate the pivotal enzymes and molecular mechani...

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Bibliographic Details
Main Authors: Jie‐Fu Fan, Xing Tan, Wen Wang, Ji‐Kui Li, Yu‐Chen Xiao, Wei‐Zhong Wang, Yang‐Kai Wang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiotensin II
cyclooxygenase
hypertension
oxidative stress
prostaglandin E2
rostral ventrolateral medulla
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.036762

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.124.036762

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