Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA

Summary: Eosinophils play a crucial role in host defense while also contributing to immunopathology through the release of inflammatory mediators. Characterized by distinctive cytoplasmic granules, eosinophils securely store and rapidly release various proteins exhibiting high toxicity upon extracel...

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Bibliographic Details
Main Authors: Lea Gigon, Philipp Müller, Beat Haenni, Ioan Iacovache, Maruša Barbo, Gordana Gosheva, Shida Yousefi, Alice Soragni, Christoph von Ballmoos, Benoît Zuber, Hans-Uwe Simon
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724004121