Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

Abstract In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined. Here we use multiple approaches to show for the first time that pS129...

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Bibliographic Details
Main Authors: Nagendran Ramalingam, Shan-Xue Jin, Tim E. Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P. Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V. Mosharov, Weisheng V. Chen, Shaomin Li, Dennis J. Selkoe, Ulf Dettmer
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00444-w

Internet

https://doi.org/10.1038/s41531-023-00444-w

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