miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

Hypoxia modulates reparative angiogenesis, which is a tightly regulated pathophysiological process. MicroRNAs (miRNAs) are important regulators of gene expression in hypoxia and angiogenesis. However, we do not yet have a clear understanding of how hypoxia-induced miRNAs fine-tune vasoreparative pro...

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Bibliographic Details
Main Authors: Jasenka Guduric-Fuchs, Edoardo Pedrini, Judith Lechner, Sarah E.J. Chambers, Christina L. O’Neill, Joana Mendes Lopes de Melo, Varun Pathak, Rachel H. Church, Stuart McKeown, James Bojdo, Kiran J. Mcloughlin, Alan W. Stitt, Reinhold J. Medina
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
vascular repair
miRNA
hypoxia
angiogenesis
endothelial progenitor
ECFC
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000159

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http://www.sciencedirect.com/science/article/pii/S2162253121000159

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