Intranasal Immunization of Mice with Multiepitope Chimeric Vaccine Candidate Based on Conserved Autotransporters SigA, Pic and Sap, Confers Protection against <i>Shigella flexneri</i>

Intranasal Immunization of Mice with Multiepitope Chimeric Vaccine Candidate Based on Conserved Autotransporters SigA, Pic and Sap, Confers Protection against <i>Shigella flexneri</i>

Shigellosis is a diarrheal disease and the World Health Organization prompts the development of a vaccine against <i>Shigella flexneri</i>. The autotransporters SigA, Pic and Sap are conserved among <i>Shigell</i>a spp. We previously designed an in silico vaccine with immunod...

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Bibliographic Details
Main Authors: Yrvin León, Lionel Zapata, Raúl E. Molina, Gaj Okanovič, Leonardo A. Gómez, Carla Daza-Castro, Manuel Flores-Concha, José L. Reyes, Angel A. Oñate
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Vaccines
Subjects:
bacillary dysentery
<i>Shigella flexneri</i>
mucosal immunity
autotransporters
GroEL
multiepitope chimeric vaccine
Online Access:https://www.mdpi.com/2076-393X/8/4/563

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https://www.mdpi.com/2076-393X/8/4/563

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