Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model

Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model

Excessive fluoride intake poses health risks to humans and animals. Many studies have indicated that fluoride exposure can damage the cytoskeleton and synapses, which has negative effects on the intellectual development of humans and animals. Our previous study suggested that the RhoA/ROCK signallin...

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Bibliographic Details
Main Authors: Chen Lingli, Ning Hongmei, Jia Penghuan, Zhang Hongli, Liu Yuye, Wang Rui, Ren Fei, Yin Zhihong, Hu Dongfang, Ge Yaming
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Fluoride
Neurotoxicity
RhoA/ROCK signalling pathway
Cytoskeleton
Fasudil
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323010588

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http://www.sciencedirect.com/science/article/pii/S0147651323010588

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