mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice

mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice

Withdrawal from binge-drinking increases negative affect, coinciding with increased expression of the metabotropic glutamate receptor 5 (mGlu5) within the shell of the nucleus accumbens (AcbSh). Supporting a causal-effect relationship, systemic treatment with the mGlu5 receptor antagonist MTEP [3-((...

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Bibliographic Details
Main Authors: Kaziya M. Lee, Michal A. Coelho, MacKayla A. Class, Kimberly R. Sern, Mark D. Bocz, Karen K. Szumlinski
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
binge drinking
adolescence
group 1 metabotropic glutamate receptors
anxiety
depression
alcoholism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01306/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01306/full

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