Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs

Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs

Abstract Background Assessing the long term effects of many surgical interventions tested in pragmatic RCTs may require extended periods of participant follow-up to assess effectiveness and use patient-reported outcomes that require large sample sizes. Consequently the RCTs are often perceived as be...

Full description

Bibliographic Details
Main Authors: Nick R. Parsons, Nigel Stallard, Helen Parsons, Aminul Haque, Martin Underwood, James Mason, Iftekhar Khan, Matthew L. Costa, Damian R. Griffin, James Griffin, David J. Beard, Jonathan A. Cook, Loretta Davies, Jemma Hudson, Andrew Metcalfe
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Medical Research Methodology
Subjects:
Adaptive designs
Interim analysis
Early outcomes
Randomized controlled trials
Surgery
Online Access:https://doi.org/10.1186/s12874-022-01734-2

Internet

https://doi.org/10.1186/s12874-022-01734-2

Similar Items