Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs

Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs

Abstract Background Assessing the long term effects of many surgical interventions tested in pragmatic RCTs may require extended periods of participant follow-up to assess effectiveness and use patient-reported outcomes that require large sample sizes. Consequently the RCTs are often perceived as be...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Nick R. Parsons, Nigel Stallard, Helen Parsons, Aminul Haque, Martin Underwood, James Mason, Iftekhar Khan, Matthew L. Costa, Damian R. Griffin, James Griffin, David J. Beard, Jonathan A. Cook, Loretta Davies, Jemma Hudson, Andrew Metcalfe
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: BMC 2022-10-01
Sarja:BMC Medical Research Methodology
Aiheet:
Adaptive designs
Interim analysis
Early outcomes
Randomized controlled trials
Surgery
Linkit:https://doi.org/10.1186/s12874-022-01734-2

Internet

https://doi.org/10.1186/s12874-022-01734-2

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