Renal cancer-derived exosomes induce tumor immune tolerance by MDSCs-mediated antigen-specific immunosuppression

Renal cancer-derived exosomes induce tumor immune tolerance by MDSCs-mediated antigen-specific immunosuppression

Abstract Backgound Although Myeloid-derived suppressor cells (MDSCs) have a prominent ability to suppress the immune responses of T lymphocytes and propel tumor immune escape, a lack of profound systemic immunesuppression in tumor-bearing mice and tumor patients. The underlying mechanism of these re...

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Bibliographic Details
Main Authors: Yingying Gao, Haoyu Xu, Nan Li, Hexi Wang, Lei Ma, Shiyou Chen, Jiayu Liu, Yongbo Zheng, Yao Zhang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cell Communication and Signaling
Subjects:
RDEs
MDSCs
Antigen-specificity
Tumor immune escape
HSP70
Online Access:http://link.springer.com/article/10.1186/s12964-020-00611-z

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http://link.springer.com/article/10.1186/s12964-020-00611-z

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