UMI-Gen: A UMI-based read simulator for variant calling evaluation in paired-end sequencing NGS libraries

UMI-Gen: A UMI-based read simulator for variant calling evaluation in paired-end sequencing NGS libraries

Motivation: With Next Generation Sequencing becoming more affordable every year, NGS technologies asserted themselves as the fastest and most reliable way to detect Single Nucleotide Variants (SNV) and Copy Number Variations (CNV) in cancer patients. These technologies can be used to sequence DNA at...

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Bibliographic Details
Main Authors: Vincent Sater, Pierre-Julien Viailly, Thierry Lecroq, Philippe Ruminy, Caroline Bérard, Élise Prieur-Gaston, Fabrice Jardin
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Sequence analysis
UMI
Simulator
Variant calling
NGS
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020303640

Internet

http://www.sciencedirect.com/science/article/pii/S2001037020303640

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