Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC

Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC

Abstract Chemodynamic therapy (CDT) based on intracellular Fenton reaction to produce highly cytotoxic reactive oxygen species (ROS) has played an essential role in tumor therapy. However, this therapy still needs to be improved by weakly acidic pH and over-expression of glutathione (GSH) in tumor m...

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Bibliographic Details
Main Authors: Wenting Chen, Fangfang Hu, Qian Gao, Caiyun Zheng, Que Bai, Jinxi Liu, Na Sun, Wenhui Zhang, Yanni Zhang, Kai Dong, Tingli Lu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Nanobiotechnology
Subjects:
Chemodynamic therapy
Reactive oxygen species
Gallic acid
Fenton reaction
Metal-polyphenol networks
Online Access:https://doi.org/10.1186/s12951-024-02308-8

Internet

https://doi.org/10.1186/s12951-024-02308-8

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