Optimization of the Detection Method for Phosphorylated α-Synuclein in Parkinson Disease by Skin Biopsy

Optimization of the Detection Method for Phosphorylated α-Synuclein in Parkinson Disease by Skin Biopsy

Background: Recent studies have found deposition of phosphorylated α-synuclein (p-syn) in Parkinson disease (PD) patients' skin, indicating p-syn may be a potential biomarker of PD. However, the sensitivity of the p-syn detection varied largely from 5. 3 to 100%, this influenced the clinical us...

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Bibliographic Details
Main Authors: Xiaojing Liu, Jing Yang, Yanpeng Yuan, Qian He, Yuan Gao, Chenyang Jiang, Lanjun Li, Yuming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neurology
Subjects:
skin biopsy
Parkinson's disease
phosphorylated a-synuclein
section thickness
biopsy sites
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.569446/full

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https://www.frontiersin.org/article/10.3389/fneur.2020.569446/full

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