DAXX-ATRX regulation of p53 chromatin binding and DNA damage response

DAXX-ATRX regulation of p53 chromatin binding and DNA damage response

The tumor suppressor proteins DAXX and ATRX are frequently mutated in cancers with alternative lengthening of telomeres (ALT). This study shows that DAXX-ATRX regulates p53 chromatin accessibility and DNA damage response and that disruption of this pathway is critical for ALT cell survival.

Bibliographic Details
Main Authors: Nitish Gulve, Chenhe Su, Zhong Deng, Samantha S. Soldan, Olga Vladimirova, Jayamanna Wickramasinghe, Hongwu Zheng, Andrew V. Kossenkov, Paul. M. Lieberman
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32680-8

Internet

https://doi.org/10.1038/s41467-022-32680-8

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