The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation

The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation

Background: The rs17618244 G>A β-Klotho (KLB) variant has been associated with increased risk of ballooning and inflammation in pediatric patients with metabolic associated fatty liver disease (MAFLD), by reducing KLB expression. In hepatocytes, KLB downregulation induced fat accumulation and the...

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Bibliographic Details
Main Authors: Nadia Panera, Marica Meroni, Miriam Longo, Annalisa Crudele, Luca Valenti, Emanuele Bellacchio, Luca Miele, Valentina D'Oria, Erika Paolini, Marco Maggioni, Anna Ludovica Fracanzani, Anna Alisi, Paola Dongiovanni
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:EBioMedicine
Subjects:
MAFLD
Liver damage
HSCS activation
protein stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000426

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421000426

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