Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs

The range of Hedgehog (Hh) signalling in the Drosophila imaginal disc is limited by Hh/receptor degradation at the anterior/posterior (A/P) compartment boundary. Here, the authors show that degradation is mediated by co-receptor proteins Ihog/Boi, whose cell adhesion functions also contribute to A/P...

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Bibliographic Details
Main Authors: Elaine Y. C. Hsia, Ya Zhang, Hai Son Tran, Agnes Lim, Ya-Hui Chou, Ganhui Lan, Philip A. Beachy, Xiaoyan Zheng
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01364-z