Identification of Potential Antiviral Inhibitors from Hydroxychloroquine and 1,2,4,5-Tetraoxanes Analogues and Investigation of the Mechanism of Action in SARS-CoV-2

Identification of Potential Antiviral Inhibitors from Hydroxychloroquine and 1,2,4,5-Tetraoxanes Analogues and Investigation of the Mechanism of Action in SARS-CoV-2

This study aimed to identify potential inhibitors and investigate the mechanism of action on SARS-CoV-2 ACE2 receptors using a molecular modeling study and theoretical determination of biological activity. Hydroxychloroquine was used as a pivot structure and antimalarial analogues of 1,2,4,5 tetraox...

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Bibliographic Details
Main Authors: Ryan S. Ramos, Rosivaldo S. Borges, João S. N. de Souza, Inana F. Araujo, Mariana H. Chaves, Cleydson B. R. Santos
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
COVID-19
antiviral
receptor-binding domain
Online Access:https://www.mdpi.com/1422-0067/23/3/1781

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https://www.mdpi.com/1422-0067/23/3/1781

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