Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report that the endocannabinoids anandamide and 2-ar...

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Bibliographic Details
Main Authors: Jack A. Jacobs, Amita Sehgal
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306872