FAD-mutation of APP is associated with a loss of its synaptotrophic activity
Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with extracellular accumulation of Aβ peptide that derives from the amyloid precursor protein (APP). While amyloidogenic processing of APP has received most attention, the physiological function of APP and the sequelae...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-08-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999610900103X |