Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment

Abstract The efficacy of immunotherapy is largely patient-specific due to heterogeneity in tumors. Combining statistic power from a variety of immunotherapies across cancer types, we found four biological pathways significantly correlated with patient survival following immunotherapy. The expression...

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Bibliographic Details
Main Authors: Naixue Yang, Fansen Ji, Liqing Cheng, Jingzhe Lu, Xiaofeng Sun, Xin Lin, Xun Lan
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-021-00175-2