Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells

Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells

Abstract Background Native bone marrow (BM) mesenchymal stem/stromal cells (BM-MSCs) participate in generating and shaping the skeleton and BM throughout the lifespan. Moreover, BM-MSCs regulate hematopoiesis by contributing to the hematopoietic stem cell niche in providing critical cytokines, chemo...

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Bibliographic Details
Main Authors: Loïc Fiévet, Nicolas Espagnolle, Daniela Gerovska, David Bernard, Charlotte Syrykh, Camille Laurent, Pierre Layrolle, Julien De Lima, Arthur Justo, Nicolas Reina, Louis Casteilla, Marcos J. Araúzo-Bravo, Abderrahim Naji, Jean-Christophe Pagès, Frédéric Deschaseaux
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stromal cells
Single-cell RNA sequencing
Characterization
Transcriptomic
Human bone marrow
Biomarkers
Online Access:https://doi.org/10.1186/s13287-023-03437-x

Internet

https://doi.org/10.1186/s13287-023-03437-x

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